科研队伍
张好建

 

 最后学位:哲学博士(Ph.D.,   University of Massachusetts Medical School

 职称职务:教授

 专业方向:细胞生物学,肿瘤生物学, 干细胞生物学

 研究方向:肿瘤干细胞与肿瘤免疫机理,血液学疾病的发生机制,基因损伤与修复

 电话号码:027-68750365

 电子邮件:Haojian_Zhang@whu.edu.cn


文化经历    

1997-2001 山东师范大会员物系生命科学专业, 学士    

2001-2004 中科会动物所细胞生物学专业, 硕士    

2006-2008 美国杰克逊研究所分子细胞生物学专业, 博士研究生    

2008-2012 美国麻萨诸塞大学医学会肿瘤生物学专业,博士    

                   

工作经历与任职    

2004-2006 中科会上海药物所,研究助理    

2012    美国麻萨诸塞大学医学会,博士后    

2012-2016 美国Dana Farber肿瘤研究所,哈佛医学会,Research Fellow

2016-至今 澳门百老汇4001登录网站教授    

         

获奖情况    

2006-2008 美国杰克逊研究所奖学金    

2010    美国血液学协会年会Travel奖    

2013-2016 美国Leukemia Lymphoma Society Fellow奖      

2016    哈佛大学华人学者生命科学杰出研究奖    

           

代表性论文          

1.  Zhang H, Kozono D, O’Connor K, Vidal-Cardenas S, Rousseau A, Hamilton A, Moreau L, Gaudiano E, Greenberger J, Bagby G, Soulier J, Grompe M, Parmar K, D’Andrea A (2016). TGF-β inhibition rescues hematopoietic stem cell defects and bone marrow failure in fanconi anemia. Cell Stem Cell 18, 1-14.

2.Zhang H, Peng C, Zhi S, Hu Y, Li H, Chen Y, Sullivan C, Cerny J, Hutchinson L, Higgins A, Miron P, Li D, Green M, Li S (2012). The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nature Genetics 44 (8): 861-871.    

3.Zhang H*, Li S (2016). Induction of chronic myeloid leukemia in mice. Methods Mol. Bio. In Press. (*Corresponding author)    

4. Zhang H*, Li S, Li H (2014). Management and orphan drugs development for acute myeloid leukemia. Expert Opinion on Orphan Drugs. 5:441-451. (*Corresponding author)    

5.  Zhang H, Li S (2013)Molecular Mechanisms for survival regulation of chronic myeloid leukemia stem cells. Protein Cell. 4:186-196.    

6.Yang Z, Zhang H, Ma L, Peng C, Chen Y, Wang J, Green M, Li S, Rosmarin A (2013). Transcriptional factor GABP is required for hematopoietic stem cell cycling and development of chronic myeloid leukemia through regulating PRKD2 kinase. PNAS 110(6): 2312-7.      

7.  Zhang H, Li S (2013). DNA Microarray Assay Helps to Identify Functional Genes Specific for Leukemia Stem Cells. Dataset Papers in Science, Article ID 520285.      

8. Ho N, Li A, Li S, Zhang H* (2012). Heat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignancies. Pharmaceuticals 5: 779-801. (*Corresponding author)    

9.Zhang H, Li H, Ho N, Li D, Li S (2012). Scd1 plays a tumor suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemiaMol. Cell. Biol.  32:1776-1787 (Spotlight Article).      

10.  Zhang H, Li H, Xi H, Li H (2012). HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells.Blood 119(11): 2595-2607.      

11.  Peng C, Chen Y, Shan Y, Zhang H, Guo Z, Li D, Li S (2012). LSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemia stem cells. PLoS One 7(6): e38614    

12.  Sullivan C, Chen Y, Shan Y, Hu Y, Peng C, Zhang H, Kong L, Li S (2011). Functional ramifications for the loss of p-selectin expression on hematopoietic and leukemic stem cells. PLoS One 2011 6 (10):e26246      

13.  Peng C, Chen Y, Yang Z, Zhang H, Osterby L, Rosamrin AG, Li S (2010). PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemia in mice. Blood 115:626-635.      

14.  Chen Y, Hu Y, Zhang H, Peng C, Li S (2009). Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nature Genetics. 41(7): 783-792.

15.  Zhang H, Wang ZZ (2008). Mechanisms that mediate stem cell self-renewal and

   differentiation. J. Cell Biochem. 103(3): 709-718.

16.  Yang YX, Miao ZC, Zhang H, Wang Y, Gao JX, Feng MF (2007). Establishment and characterization of a human telomerase catalytic submit-transduced fetal bone marrow-derived osteoblastic cell line. Differentiation 75 (1): 24-34.

17.  Zhang H, Miao Z, He Z, Yang Y, Wang Y, Feng M (2005). The existence of epithelial-to-mesenchymal cells with the ability to support hematopoiesis in human fetal liver. Cell Biol. Int. 29 (3): 213-219.

18.  He ZP, Tan WQ, Tang YF, Zhang H, Feng MF (2004). Activation, isolation, identification and in vitro proliferation of oval cells from adult rat livers. Cell Prolif. 37 (2):177-187.

19.  Zhang HMiao ZWang YFeng M (2004). Regulation of haematopoietic stem cells self-renenwal and the role of Wnt signaling in the process. Prog. Biochem. Biophys. 31 (7): 579-583.

20.  Zhang H, He Z, Feng M (2004). Progress in fetal liver stem cell. Cell Biol. of Chin. 26 (1): 1-6.

 

21.  He Z, Zhang H, Wang Y, Wang J, Feng M (2003). Progress on plasticity of hepatic stem cells and the mechanisms governing their differentiation. Prog. Biochem. Biophys 30 (6): 864-867.

 

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