科研队伍
周严

 最后学位医学博士/理学博士(MD/PhD,北京协和医学会

 职称职务:教授、博导

 专业方向:发育神经生物学developmental neuroscience)

 研究方向:脑发育机制与神经系统疾病

 电话号码:027-68756689

 电子邮件:yan.zhou@whu.edu.cn

 

工作经历与任职

2002-2007 耶鲁大学 博士后

2007-2011 耶鲁大学 副研究科学家(Associate Research Scientist)

2011-2017 澳门百老汇生命科学学会 教授、博士生导师、系主任(2015-2017)

2017-至今 澳门百老汇4001登录网站 教授、博士生导师、实验动物中心主任(2018-)

 

获奖及荣誉  

澳门百老汇珞珈学者特聘教授(2011

文化部新世纪优秀人才支撑计划2012

湖北省优秀学士学位论文引导教员(2013

澳门百老汇弘毅学堂优秀文化工编辑 2016

澳门百老汇第八届青年教员教学竞赛三等奖(2016

澳门百老汇生命科学学会我心中的优秀班级导师2018

 

主要社会兼职

中国细胞生物学学会理事(2019 -

中国神经科学学会神经发育与再生分会委员(2016 -

湖北省细胞生物学学会理事(2013 -

Cerebral Cortex, JMCB, Molecular Brain, Scientific Reports, Cell Cycle, PLoS One, Journal of Neurochemistry等杂志审稿人

  

研究领域及兴趣

人脑特别是大脑皮层是自然界最复杂、最为精密的结构;脑疾患产生严重的健康、经济和社会问题。脑发育的核心问题之一是神经元和胶质细胞如何精密地产生、空间上准确定位并形成功能神经环路。本课题组综合应用发育生物学、遗传学、细胞生物学和生物化学方法研究哺乳动物大脑皮层发育过程中神经前体细胞如何进行命运选择,尤其是皮层投射神经元顺序产生的分子和细胞生物学机制。特别关注组蛋白修饰、长非编码RNA和基因组顺式元件的转录调控功能。并发现这些调控机制与多种神经系统疾病如自闭症、先天性智力障碍、神经退行性疾病和神经系统肿瘤等的发生发展密切相关。

The six-layer structure of the cerebral cortex (neocortex) of the brain is amazingly complex. We explore the molecular and cellular mechanisms governing the precise generation of cellular components of the neocortex by neural progenitor cells, with emphasis on roles of histone modifications, long non-coding RNAs and cis-regulatory elements in transcriptional regulation. Our findings have implications in understanding pathogenesis of neurological disorders including autism, intellectual disability, neural degeneration and glioma.

 

承担课程

动物与人类发育生物学(2013-),生命科学学会本科生课程

 

代表性论文

1. Li W, Shen W, Zhang B, Tian K, Li Y, Mu L, Luo Z, Zhong X, Wu X, Liu Y*, Zhou Y*. (2019) Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b, Protein & Cell, doi.org/10.1007/s13238-019-0650-z

2. Luo, Z, Mu L, Zheng Y, Shen W, Li J, Xu L, Zhang B, Liu Y*, Zhou Y*. (2019) NUMB enhances Notch signaling by repressing ubiquitination of NOTCH intracellular domain, Journal of Molecular Cell Biology, doi.org/10.1093/jmcb/mjz088

3. Liu Y, Zhou Q, Zhong L, Lin H, Hu MM, Zhou Y*, Shu HB*, Li S*. (2018) ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association, Cellular and Molecular Immunology, 5(10):907-916

4. Dong F, Li Q, Yang C, Huo D, Wang X, Ai C, Kong Y, Sun X, Wang W, Zhou Y, Liu X, Li W, Gao W, Liu W, Kang C, Wu X*. (2018) PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma. Nature Communications, 9(1):4552

5. Wang A, Wang J, Liu Y*, Zhou Y*. (2017) Mechanisms of long non-coding RNAs in the assembly and plasticity of neural circuitry, Frontiers in Neural Circuits, 11:76

6. Li Y, Wang W, Wang F, Wu Q, Li W, Zhong X, Tian K, Zeng T, Gao L, Liu Y, Li S, Jiang X, Du G, Zhou Y*. (2017) Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells, Journal of Molecular Cell Biology, 9(4):302-314

7. Zhong X, Liu X, Li Y, Cheng M, Wang W, Tian K, Mu L, Zeng T, Liu Y, Jiang X, Gao L, Zhou Y*. (2016) HMGA2 promotes self-renewal and invasiveness of glioma-initiating cells, Oncotarget, 7(28): 44365-44380.

8. Cheng M, Jin X, Mu L, Li W, Zhong X, Liu X, Shen W, Liu Y*, Zhou Y*. (2016) Combination of the clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 technique with the piggybac transposon system for mouse in utero electroporation to study cortical development. Journal of Neuroscience Research, 94(9): 814-824. (cover story)

9. Zhou Y* (2012). Cortical development and asymmetric cell division. Frontiers in Biology, 7(4): 297-306.

10. Zhou Y, Atkins J, Rompani S, Bancescu D, Tang H, Petersen P, Zou K, Stewart S, Zhong W* (2007). The mammalian Golgi regulates Numb signaling in asymmetric cell division by releasing ACBD3 during mitosis. Cell, 129 (1): 163-78 (highlighted in F1000)

11. Zhou Y, Du G, Hu X, Yu S, Liu Y, Xu Y, Huang X, Liu J, Yin B, Fan M, Peng X, Qiang B, Yuan J* (2005). Nectin-like molecule 1 is a protein 4.1 N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. Biochimica et Biophysica Acta-Biomembranes, 1669(2): 142-54.

12. Tang H, Rompani S B, Atkins J B, Zhou Y, Osterwalder T, and Zhong W* (2005). Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway. Molecular and Cellular Biology, 25: 2899-2909.

13. Zhou Y, Hu S, Huang X, Zhou H, Tan X, Peng X, Qiang B, Yuan J* (2002). Construction of human and mouse brain cDNA libraries and isolation of full-length cDNAs. Progress in Natural Science, 12(6): 477-480.

14. Wang J, Zhou Y, Yin B, Du G, Huang X, Li G, Shen Y, Yuan J, and Qiang B* (2001). ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines. Journal of Molecular Medicine, 79, 399-405.

15. Zhou Y, Du G, Wang J, Chen J, Yuan J, Qiang B* (1999). Isolation and cloning of a novel cDNA LDB1 encoding human LIM domain binding protein. Chinese Science Bulletin, 44(12): 1114-1119.

16.《基因组》主译:袁建刚 周严 强伯勤(原著Genomes by Brown, T.A., 2000 ISBN 7-03-010114-6/Q.1136

 

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