科研队伍
蒋卫

最后学位:理学博士(PhD,北京大学)

职称职务:教授                   

专        业:细胞生物学、发育生物学                   

研究方向:干细胞生物学和表观遗传调控                   

电话号码:027-68750399

电子邮件:jiangw.mri@whu.edu.cn        

 

文化经历
2001-2005 北京大会员命科学学会生物科学专业,学士
2005-2010 北京大会员命科学学会细胞生物学专业,博士

工作经历与任职  

2011-2012 美国霍华德休斯医学研究所及北卡罗莱纳大学教堂山分会,博士后
2012-2015 美国霍华德休斯医学研究所及哈佛医学会、波士顿儿童医会,博士后
2015-         澳门百老汇4001登录网站教授、中南医会特聘研究员  


研究兴趣:

干细胞分化,表观遗传学调控,长非编码RNA,疾病模型,糖尿病

本实验室的长期兴趣是结合发育生物学和遗传学/表观遗传学的基础研究,应用于多能干细胞分化模型来揭示疾病发生的分子机制,关注点是组蛋白修饰、长非编码RNA以及细胞代谢层面的细胞命运决定的分子调控;同时以此获得功能性细胞用于再生医学。研究手段主要包括人多能干细胞建立和维持、定向诱导分化(内胚层和胰腺方向),基因组编辑以及组织工程。目前受中组部千人计划青年项目、国家自然科学基金委重大研究计划培育项目和面上项目、科技部重点研发专项项目支撑。


获奖、荣誉、学术兼职  

HMS Epigenetics Initiative Travel Grant (2015);

Juvenile Diabetes Research Foundation (JDRF) Postdoctoral Fellowship (2012-2015);

Beta Cell Biology Consortium (BCBC) Investigator Retreat, Scholarship (2012, 2013);

Science Bulletin 青年编委(2019-)  

杂志审稿人: Cell Reports, Stem Cells, Seminars in Cell and Developmental Biology, Stem Cell Research, Tissue Engineering, Stem Cells and Development, Stem Cells Translational Medicine, Experimental Cell Research, Stem Cell Reviews and Reports, Cellular Reprogramming, Journal of Diabetes Research, Molecular and Cellular Biochemistry, Stem Cell International


发表论文概述
已在国际刊物发表论文 30 篇,被 SCI 引用 1800 余次,第一编辑论文单篇最高被引用 300 余次。


代表性论文( 11 out of 30 )

1.   Ting Geng, Donghui Zhang, Wei Jiang#. (2019). Concise Review: Epigenetic Regulation of Transition among Different Pluripotent States. Stem Cells. 37(11):1372-1380.

2. Yinglei Li, Wei Jiang#. (2019). The path and surface marker of SC-β cells. Science Bulletin. 64(16), 1122-1124.

3. Xiaojuan Su*, Mengtian Tan*, Bo Duan, Jie Cai#, Wei Jiang#, Lina Zhang#. (2019). Hierarchical microspheres with macropores fabricated from chitin as 3D cell culture. Journal of Materials Chemistry B. 7(34), 5190-5198.

4. Zhang D#, Jiang W#. (2015). From one-cell to tissue: reprogramming, cell differentiation and tissue engineering. Bioscience 65 (5): 468-475.

5.  Jiang W#, Liu Y, Liu R, Zhang K, Zhang Y#. (2015). LncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression. Cell Reports 11(1), 137–148.

6.  Jiang W#, Zhang D, Bursac N, Zhang Y#. (2013). WNT3 is a biomarker capable of predicting definitive endoderm differentiation potential of hESCs. Stem Cell Reports 1 (1), 46-52.

7.  Jiang W, Wang J, Zhang Y#. (2013). Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. Cell Research 23(1), 122-130.    

8.  Jiang W*, Sui X*, Zhang D, Liu M, Ding M, Shi Y#, Deng H#. (2011). CD24: A novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells. Stem Cells 29(4):609-617.

9.   Zhang D*, Jiang W*, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H #. (2009). Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Research 19(4):429-438. (* co-first authors) 封面文章;被同期专文评述关注;获赛诺菲 - 安万特 Cell Research 2009 年度最佳研究论文奖

10.   Jiang W*, Bai Z *, Zhang D, Shi Y, Yong J, Chen S, Ding M, Deng H # . (2008). Differentiation of mouse nuclear transfer embryonic stem cells into functional pancreatic beta cells. Diabetologia 51:1671-1679.

11.   Jiang W*, Shi Y*, Zhao D, Chen S, Yong J, Zhang J, Qing T, Sun X, Zhang P, Ding M, Li D#, Deng H#. (2007). In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Research 17:333-344.    


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