科研队伍
Youngnam Jin

 


 最后学位:哲学博士(PhD,美国罗切斯特大学)

 职称职务:教授、博导

 专业方向:生物化学、药理学

 研究方向:化会员物学、RNA生物学、胚胎发育、细胞谱系程序化、神经疾病和癌症的翻译调控

 电话号码:027-68750324

 电子邮件:youngnam_jin@whu.edu.cn 

 

文化经历

1990-1997 韩国仁荷大学,学士

1997-1999 韩国首尔大学,硕士

2003-2010 美国罗切斯特大学,博士

 

工作经历与任职

2011-2016 美国麻省总医会,博士后研究员

2017-2018 美国犹他大学,研究助理教授

2018-至今 澳门百老汇4001登录网站,教授

 

获奖情况

2015 美国NIH博士后奖学金,奖励编号:5T32HL7208-38

2014 麻省总医会科学促进会(Scientific Advisory Committee)最佳墙报奖

2014 Keystone大会基金奖(Keystone Symposia Scholarship

2009 罗切斯特大学医学会理事会(Medical Faculty Council)基础医学差旅奖金

 

研究领域

   主要从事药物筛选和药理学方面的研究。曾系统阐述了线粒体的代谢参与神经退行的过程。曾发现了一种全新的非经典蛋白翻译途径:poly(A)-tail independent non-canonical translationPAINT)以及由化学筛选得到的、特异影响这一途径的小分子化合物primordazine;并从分子水平阐明了PAINT蛋白翻译途径的机理。目前实验室以斑马鱼和细胞系为模型,深入研究PAINT的机理;并在神经疾病和癌症模型中进行化学筛选,研究靶点药物的机制。

 

代表性论文

1. Jin YN*#, Schlueter PJ*, Jurisch-Yaksi N, Lam PY, Jin S, Hwang, WY, Yeh JR, Yoshigo M, Ong SE, Schenone M, Hartigan CR, Carr SA, Peterson RT#. (2018) Non-canonical translation via deadenylated 3’UTRs maintains primordial germ cells. Nat Chem Biol. doi: 10.1038/s41589-018-0098-0

2. Metelo AM, Noonan HR, Li X, Jin Y, Baker R, Kamentsky L, Zhang Y, van Rooijen E, Shin J, Carpenter AE, Yeh JR, Peterson RT, Iliopoulos O. (2015) Pharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model. J Clin Invest. 125(5):1987-97. 

3. Nath AK, Ryu JH, Jin YN, Roberts LD, Dejam A, Gerszten RE, Peterson RT. (2015) PTPMT1 inhibition lowers glucose through succinate dehydrogenase phosphorylation. Cell Rep. 10(5): 694-701. 

4. Jo C, Gundemir S, Pritchard S, Jin YN, Rahman I, Johnson GVW. (2014) Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52. Nat Commun. 5:3496. 

5. Quintanilla RA, Jin YN, von Bernhardi R, Johnson GV. (2013) Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease. Mol Neurodegener. 8:45. 

6. Jin YN, Yanxun VY, Gundemir S, Jo C, Cui M, Tieu K, Johnson GVW. (2013) Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin. PLoS One 8(3):e57932. 

7. Kokel D, Cheung CYJ, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT. (2013) Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 9(4):257-63. 

8. Jin S, Sarkar KS, Jin YN, Liu Y, Kokel D, Van Ham TJ, Roberts LD, Gerszten RE, MacRae CA, Peterson RT..(2013) An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action. J Biomol Screen. 18(1):108-15. 

9. Jin YN, Chen PC, Watson JA, Walters BJ, Phillips SE, Green K, Schmidt R, Wilson JA, Johnson GV, Roberson ED, Dobrunz LE, Wilson SM. (2012) Usp14 deficiency increases Tau phosphorylation without altering tau degradation or causing tau-dependent deficits. PLoS One 7(10):e47884. 

10. Jin YN, Hwang WY, Jo C, Johnson GV. (2012) Metabolic state determines sensitivity to cellular stress in Huntington disease: normalization by activation of PPARγ. PLoS One 7(1):e30406. 

11. Quintanilla RA, Dolan PJ, Jin YN, Johnson GV. (2012) Truncated tau and Aβ cooperatively impair mitochondria in primary neurons. Neurobiol Aging. 33(3):619.e25-35. 

12. Dolan PJ, Jin YN, Hwang W, Johnson GV. (2011) Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356. FEBS Lett. 585(21):3424-9. 

13. Jin YN and Johnson GVW. (2010) The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease. J Bioenerg Biomembr. 42(3):199-205. 

14. Quintanilla RA, Jin YN, Fuenzalida K, Bronfman M, and Johnson GVW. (2008) Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPAR?) in the pathogenesis of Huntington disease. J Biol. Chem. 283(37):25628-37. 

15. Crimmins S, Jin Y, Wheeler C, Huffman AK, Chapman C, Dobrunz LE, Levey A, Roth KA, Wilson JA, and Wilson SM. (2006) Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14. J Neurosci. 26(44):11423-31.

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