Hu-Dan Liu
Author:  Date:2015-10-06  Clicks:

Professor

Department of Cancer Biology

Medical Research Institute

Wuhan University School of Medicine

Wuhan, China

Email:  hudanliu@whu.edu.cn

Tel:027-68750308

Hu-Dan Liu, PhD


Education: 

Ph.D. in Cell and Development Biology 2005

Rutgers, the State University of New Jersey, NJ, USA


Research Areas:

1. We focus o understanding molecular pathology of tumorigenesis using multiple in vitro and in vivo approaches with particular attentions on major oncogenes, NOTCH and MYC.

2. We attempt to develop novel, mechanism-based targeted or combination therapy in cancer treatment, and evaluate the efficacy and safety in pre-clinical murine models.


Selected Publications: (* corresponding author)

1. Su H, Hu J, Huang L, Yang Y, Thenoz M, Kuchmiy A, Hu Y, Li P, Feng H, Zhou Y, Taghon T, Vlierberghe PV, Qing G, Chen Z* & Liu H*. SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival. Nature Communications. 2018, 9(1):4281.

2. Yue M, Jiang J, Gao P, Liu H*, Qing G*. Oncogenic MYC activates a feedforward regulatory loop promoting essential amino acid metabolism and tumorigenesis. Cell Reports. 2017, 21(13):3819-3832.

3. Wang Z, Hu Y, Xiao D, Wang J, Liu C, Xu Y, Shi X, Jiang P, Huang L, Li P, Liu H*, Qing G*. Stabilization of Notch1 by the Hsp90 Chaperone Is Crucial for T-Cell Leukemogenesis. Clinical Cancer Research. 2017, 23(14):3834-3846.

4. Hu Y, Su H, Ye Q, Wang Z, Huang L, Wang Q, Liu S, Chen S, Zhou J, Li P, Liu H*, Qing G*. DEPTOR is a direct NOTCH1 target that promotes proliferation and survival in T-cell leukemia. Oncogene. 2017, 36(8):1038-1047.

5. Ye Q, Jiang J, Zhan G, Yan W, Huang L, Hu Y, Su H, Tong Q, Yue M, Li H, Yao G*, Zhang Y*, Liu H*. Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia. Scientific Reports. 2016;6:26510.

6. Ye Q, Yao G , Zhang M, Guo G, Hu Y, Jiang J, Cheng L, Li H, Qing G, Zhang Y*, Liu H*. A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/b-catenin signaling. Carcinogenesis. 2015, 36(3): 318-26.

7. Hu Y, Su H, Li X, Guo G, Qin R, Qing G, Liu H*. The NOTCH ligand JAGGED2 promotes pancreatic cancer metastasis independent of Notch signaling activation. Molecular Cancer Therapeutics. 2015, 14(1): 289-297.

8. Liu H, Chi AWS, Chiang MY, Arnett KL Xu L, Shestova O, Wang H, Li Y, Bhandoola A, Aster JC, Blacklow SC, Pear WS*. Notch dimerization is required for leukemogenesis and T cell development. Genes and Development. 2010, 24(21):2395-407.


Tel: 0086-27-68750205 Fax: 0086-27-68759675  Email: mri@whu.edu.cn

Contact address: Donghu Road, No. 115, Wuchang District, Wuhan, Hubei Province, P.R. China. 430071

Copyright @ 2016 Medical Research Institute

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