Che-guo Cai
Author:  Date:2017-11-17  Clicks:



Tel: 86-27-68750185






Research Fields

Molecular mechanisms of adult stem cell self-renewal

Molecular mechanisms of stem cell interact with immune cells

Cellular origin and therapy of breast cancer



2007 – 2010 Ph.D. Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China. Supervisor: Paul Zhou

2002 – 2005 M.S. School of Life Sciences, Xiamen University, Xiamen, China

1998 – 2002 B.S. School of Life Sciences, Xiamen University, Xiamen, China



2017.02 – Present: Principle Investigator/Professor, Medical Reseach Institute, Wuhan University, Wuhan, Hubei, CHINA

2015 – 2016: Associate Professor, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

2012 – 2014: Postdoctoral fellow, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

2010 – 2011: Postdoctoral fellow, Department of Medicine, Tulane Health Sciences Center, Tulane University, New Orleans, LA, USA



2013/01-2015/12  National Natural Science Foundation of China for The Youth.

2017/01-2020/12  General Program of National Natural Science Foundation of China.

2012/01-2015/12  China Postdoctoral Science Foundation.

     2016/01-2019/12  Bureau of International Cooperation, The Chinese Academy of Sciences.


Selected publications

Zeng L+, Cai C+, Li S, Wang W, Li Y, Chen J, Zhu X, and Zeng YA. Essential roles of Cyclin Y-like 1 and Cyclin Y in dividing Wnt responsive mammary stem/progenitor cells. PLoS Genetics, 2016 May 20; 12(5): e1006055(+Co-First Author)

Cai C, Liu W, Song W, Yang Q, Li D, Yang L, Zeng YA. A novel Function of Rspondin1 in Regulating Estrogen Receptor Expression Independent of Wnt/β-Catenin Signaling. Manuscript preparation.

Wang D+, Cai C+, Dong X, Yu QC, Zhang XO, Yang L, Zeng YA. Identification of Multipotent Mammary Stem Cells by Protein C Receptor Expression. Nature. 2015 Jan 1; 517(7532):81-4. (+Co-First Author)

Cai C, Yu QC, Jiang W, Liu W, Song W, Yu H, Zhang L, Yang Y, Zeng YA. R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal. Genes Dev. 2014 Sep 26; 28: 22052218.

Cai C, Leslie J, Franko-Tobin L, Prasnal M,Yang T, Mackey V, Fuselier J, Coy D, Liu M, Yu C, Sun LC. Valproic acid suppresses cervical cancer tumor progression possibly via activating Notch1 signaling and enhances receptor-targeted cancer chemotherapeutic via activating somatostatin receptor type II. Arch Gynecol Obstet. 2013 Feb 23: 288(2):393-400.

Ding H+, Cai C+, Gutierrez RA, Zhou F, Buchy P, Deubel V, Zhou P. Superior neutralizing antibody response and protection in mice vaccinated with heterologous DNA prime and virus like particle boost against HPAI H5N1 virus. PLoS ONE. 2011 Jan 28: 6(1):e16563. (+Co-First Author)

Ding H+, Cai C+, Zhou F, Buchy P, Deubel V, Zhou P. Heterosubtypic antibody response elicited with seasonal influenza vaccine correlates with partial protection against Highly Pathogenic H5N1 virus. PLoS ONE. 2011 Mar 25:6(3): e17821. (+Co-First Author)

Cai C, Caillet C, Hu H, Zhou F, Ding H, Zhang G, Zhou B, Wang S, Lu S, Buchy P, Deubel V, Vogel F, Zhou P, Measurement of neutralizing antibody responses against H5N1 clades in immunized mice and ferrets using pseudotypes expressing influenza hemagglutinin and neuraminidase. Vaccine. 2009 Sep 2: 27(48):6777-90.

Wang G, Zhou F, Buchy P, Zuo T, Hu H, Liu J, Song Y, Ding H, Cai C, Chen Z, Zhang L, Deubel V, Zhou P. DNA Prime and Virus-like Particle Boost From a Single H5N1 Strain Elicits Broadly Neutralizing Antibody Responses Against Head Region of H5 Hemagglutinin. J Infect Dis 2014, 209(5):676-85.

Hu HX, Voss J, Zhang G, Buchy P, Wang L, Wang F, Zhou F, Wang G, Cai C, Calder L, Gamblin S, Deubel V, Zhou B, Skehel J, Zhou P. A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses. Journal of Virology 2012, 86(6): 2978-89.

Li R, Qin Y, He Y, Tao WY, Zhang N, Cai C, Zhou P, and Zhong J. Production of Hepatitis C Virus Lacking the Envelope-Encoding Genes for Single-Cycle Infection by Providing Homologous Envelope Proteins or Vesicular Stomatitis Virus Glycoproteins in trans. Journal of Virology  2011, 85:2138–2147.

Wang W, Ren P, Mardi S, Hou L, Cai C, Chan KH, Cheng P, Sheng J, Buchy P, Sun B, Toyoda T, Lim W, Peiris JS, Zhou P, Deubel V. Design of multiplexed detection assays for identification of avian influenza a virus subtypes pathogenic to humans by SmartCycler real-time reverse transcription-PCR. J Clin. Microbiol 2009, 47:86-92.










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