Hong-Bing Shu
Author:  Date:2015-10-19  Clicks:

Elected Member, Chinese Academy of Sciences      

Professor and Director, Medical Research Institute

Vice President, Wuhan University   

Tel:              86-27-68753795

Fax:             86-27-68755692

Email:         shuh@whu.edu.cn



Hong-Bing Shu, PhD


Research Areas:

Mechanisms of innate antiviral immune responses and inflammation


Selected Publications: (10 out of 119)

1.      Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB* (2005). VISA is an adapter protein required for virus-triggered signaling. Mol Cell 19:727-740.  

2.      Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB* (2008). The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation. Immunity 29:538-550.

3.      Zhong B, Zhang L, Lei Z, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB* (2009). RNF5 negatively regulates virus-induced IRF3 activation via ubiquitination and degradation of MITA. Immunity 30:397-407.

4.      Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F, Shu HB* (2009). ISG56 is a negative feedback regulator of virus-triggered signaling and cellular antiviral response. P Natl Acad Sci USA 106:7945-7950.

5.      Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Yong, Li S, Tien P, Shu HB* (2010). WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. P Natl Acad Sci USA 107:815-820.

6.      Lei CQ, Zhong B, Zhang Y, Zhang J, Shu HB* (2010). GSK3b regulates virus-triggered IRF3 activation and cellular antiviral response by promoting TBK1 activation. Immunity 33:878-889.

7.      Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W, Shu HB* (2012). LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. P Natl Acad Sci USA  109:11770-11775.

8.      Chen R, Li M, Zhang Y, Zhou Q, Shu HB* (2012). The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation. P Natl Acad Sci USA 109:14128-14133.

9.      Yang Y, Liao B, Wang S, Jin Y, Shu HB*, Wang YY*. (2013). The E3 ubiquitin ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation. P Natl Acad Sci USA 110(13):5115-20.

10.    Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B, Shu HB*(2014). TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3. P Natl Acad Sci USA 111:1509-1514.


All Publications 

Tel: 0086-27-68750205 Fax: 0086-27-68759675  Email: mri@whu.edu.cn

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