Ming-Ming Hu
Author:  Date:2018-05-16  Clicks:



     Associate Professor, Medical Research Institute

     Tel:    86-27-68750121

       Email: mmhu@whu.edu.cn

     Research Areas:  Mechanisms of innate antiviral immune responses and inflammation  

Ming-Ming Hu, PhD

Selected Publications:

1. Yang, Q., Liu, T.T., Lin, H., Zhang, M., Wei, J., Luo, W.W., Hu, Y.H., Zhong, B., Hu, M.M.*, and Shu, H.B*. (2017) TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses. PLoS Pathog. 13(9):e1006600. (*:corresponding author)

2. Hu, M.M., Liao, C.Y., Yang, Q., Xie, X.Q., and Shu. H.B. (2017) Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5. J Exp Med. 214(4):973-989.

3. Hu, M.M. and Shu HB. (2017) Multifaceted roles of TRIM38 in innate immune and inflammatory responses. Cell Mol Immunol. 14(4):331-338.

4. Hu, M.M., Yang, Q., Xie, X.Q., Liao, C.Y., Lin, H., Liu, T.T., and Shu, H.B. (2016). Sumoylation promotes the satbility of the DNA sensor cGAS and the adaptor STING to regulate the kinetics of response to DNA virus. Immunity 45, 555-569.

5. Hu, M.M., Xie, X.Q., Yang, Q., Liao, C.Y., Ye, W., Lin, H., and Shu, H.B. (2015). TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms. J Immunol. 195, 4415-4425.

6. Hu, M.M., Yang, Q., Zhang, J., Liu, S.M., Zhang, Y., Lin, H., Huang, Z.F., Wang, Y.Y., Zhang, X.D., Zhong, B., and Shu, H.B. (2014). TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A 111, 1509-1514.

7. Fu, Y.Z., Su, S., Gao, Y.Q., Wang, P.P., Huang, Z.F., Hu, M.M., Luo, W.W., Li, S., Luo, M.H., Wang, Y.Y., and Shu, H.B. (2017) Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity. Cell Host Microbe. 21(2):231-243.

8. Yan, B.R., Zhou, L., Hu, M.M., Li, M., Lin, H., Yang, Y., Wang, Y.Y., and Shu, H.B. (2017). PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation. PLoS Pathog. 13(9):e1006648.

9. Ye, W., Hu, M.M., Lei, C.Q., Zhou, Q., Lin, H., Sun, M.S., and Shu, H.B. (2017) TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction. J Immunol. 199(5):1856-1864.

10. Chen, L.T., Hu, M.M., Xu, Z.S., Liu, Y., and Shu, H.B. (2016). MSX1 modulates RLR-mediated innate antiviral signaling by facilitating assembly of TBK1-associated complexes. J Immunol.

11. Qin, Y., Zhou, M.T., Hu, M.M., Hu, Y.H., Zhang, J., Guo, L., Zhong, B., and Shu, H.B. (2014). RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. PLoS Pathog. 10, e1004358.

12. Yan, J., Li, Q., Mao, A.P., Hu, M.M., and Shu, H.B. (2014). TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination. J Mol Cell Biol 6, 154-163.

13. Zhang, J., Hu, M.M., Shu, H.B., and Li, S. (2014). Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response. Cell Mol Immunol. 11, 245-252.

14. Zhang, J., Hu, M.M., Wang, Y.Y., and Shu, H.B. (2012). TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. J Biol Chem 287, 28646-28655.

Tel: 0086-27-68750205 Fax: 0086-27-68759675  Email: mri@whu.edu.cn

Contact address: Donghu Road, No. 115, Wuchang District, Wuhan, Hubei Province, P.R. China. 430071

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