科研队伍
胡明明

 

 最后学位:理学博士(PhD, Wuhan University)

 职称职务:特聘副研究员

 专业方向:医学免疫学

 研究方向:天然免疫与炎症反应

 电话号码:027-68750121

 电子邮件:mmhu@whu.edu.cn 

 

文化经历

2007-2011 澳门百老汇生命科学学会,学士

2011-2016 澳门百老汇生命科学学会,博士

 

工作经历与任职

2016-至今 澳门百老汇4001登录网站,特聘副研究员

 

所获荣誉与奖励

2017 澳门百老汇学术创新奖特等奖

2016 入选第一批全国优秀博士后创新人才支撑计划

2015 国家奖学金

2014 澳门百老汇学术创新奖一等奖

2012 国家奖学金

 

所获研究资助

全国优秀博士后创新人才支撑计划、自然科学基金面上项目

 

代表性论文

1. Yang, Q., Liu, T.T., Lin, H., Zhang, M., Wei, J., Luo, W.W., Hu, Y.H., Zhong, B.,Hu, M.M.*, and Shu, H.B*. (2017) TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses.PLoS Pathog.13(9):e1006600. (*:corresponding author)

2.Hu, M.M., Liao, C.Y., Yang, Q., Xie, X.Q., and Shu. H.B. (2017) Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.J Exp Med.214(4):973-989.

3.Hu, M.M. and Shu HB. (2017) Multifaceted roles of TRIM38 in innate immune and inflammatory responses.Cell Mol Immunol.14(4):331-338.

4. Fu, Y.Z., Su, S., Gao, Y.Q., Wang, P.P., Huang, Z.F.,Hu, M.M., Luo, W.W., Li, S., Luo, M.H., Wang, Y.Y., and Shu, H.B. (2017) Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.Cell Host Microbe.21(2):231-243.

5. Yan, B.R., Zhou, L.,Hu, M.M., Li, M., Lin, H., Yang, Y., Wang, Y.Y., and Shu, H.B. (2017). PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation.PLoS Pathog.13(9):e1006648.

6. Ye, W.,Hu, M.M., Lei, C.Q., Zhou, Q., Lin, H., Sun, M.S., and Shu, H.B. (2017) TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction.J Immunol.199(5):1856-1864.

7.Hu, M.M., Yang, Q., Xie, X.Q., Liao, C.Y., Lin, H., Liu, T.T., and Shu, H.B. (2016). Sumoylation promotes the satbility of the DNA sensor cGAS and the adaptor STING to regulate the kinetics of response to DNA virus.Immunity45, 555-569.

8. Chen, L.T.,Hu, M.M., Xu, Z.S., Liu, Y., and Shu, H.B. (2016). MSX1 modulates RLR-mediated innate antiviral signaling by facilitating assembly of TBK1-associated complexes.J Immunol.

9.Hu, M.M., Xie, X.Q., Yang, Q., Liao, C.Y., Ye, W., Lin, H., and Shu, H.B. (2015). TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.J Immunol.195, 4415-4425.

10.Hu, M.M., Yang, Q., Zhang, J., Liu, S.M., Zhang, Y., Lin, H., Huang, Z.F., Wang, Y.Y., Zhang, X.D., Zhong, B., and Shu, H.B. (2014). TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3.Proc Natl Acad Sci U S A111, 1509-1514.

11. Qin, Y., Zhou, M.T.,Hu, M.M., Hu, Y.H., Zhang, J., Guo, L., Zhong, B., and Shu, H.B. (2014). RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms.PLoS Pathog.10, e1004358.

12. Yan, J., Li, Q., Mao, A.P.,Hu, M.M., and Shu, H.B. (2014). TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination.J Mol Cell Biol6, 154-163.

13. Zhang, J.,Hu, M.M., Shu, H.B., and Li, S. (2014). Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response.Cell Mol Immunol.11, 245-252.

14. Zhang, J.,Hu, M.M., Wang, Y.Y., and Shu, H.B. (2012). TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination.J Biol Chem287, 28646-28655.

 

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