Yan Zhou
Author:  Date:2018-05-17  Clicks:


       Professor, Medical Research Institute

       Tel: 86-27-68756689

       E-mail: yan.zhou@whu.edu.cn

Yan Zhou, MD/PhD


Cortical development of the cerebrum; long non-coding RNAs; glioma tumorigenesis


The six-layer structure of the cerebral cortex of human brain is amazingly complex. Using modern genetic and molecular approaches, we explore the molecular and cellular mechanisms governing generation the cellular components of cortex, especially projection neurons, by neural progenitor cells in an ordered manner. We are also interested in essential properties of glioma stem cells in glioma tumorigenesis. The main research aspects include: 1) mechanisms underlying cell-fate determination of neural progenitor cells in the developing cerebral cortex; 2) characterization of long non-coding RNAs essential for cortical development; 3) properties of stem-like cells in glioma tumorigenesis.


2017-present Professor, Medical Research Institute, Wuhan University

2011-2017 Professor, Chair of Department of Cell Biology (2015-2017), College of Life Sciences, Wuhan University

2007-2010 Associate Research Scientist, Department of Molecular, Cellular and Developmental Biology, Yale University

2002-2007 Postdoctoral Associate, Department of Molecular, Cellular and Developmental Biology, Yale University

2000-2002 M.D. Peking Union Medical College, Beijing, China

1997-2000 Ph.D.  Peking Union Medical College, Beijing, China

1991-1997 B.S.   Tongji Medical College, Wuhan, China


1. Wang, A., Wang, J., Liu, Y., Zhou, Y. * (2017) Mechanisms of long non-coding RNAs in the assembly and plasticity of neural circuitry, Frontiers in Neural Circuits, doi: 10.3389/fncir.2017.00076

2. Li, Y., Wang, W., Wang, F., Wu, Q., Li, W., Zhong, X., Tian, K., Zeng, T., Gao, L., Liu, Y., Li, S., Jiang, X., Du, G., Zhou, Y.* (2017) Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells, Journal of Molecular Cell Biology, 9(4):302-314

3. Zhong, X., Liu, X., Li, Y., Cheng, M., Wang, W., Tian, K., Mu, L., Zeng, T., Liu, Y., Jiang, X., Gao, L., Zhou, Y.* (2016) HMGA2 promotes self-renewal and invasiveness of glioma-initiating cells, Oncotarget, 7(28): 44365-44380.

4. Cheng M., Jin X., Mu L., Li W., Zhong X., Liu X., Shen W., Liu Y., Zhou Y.* (2016). Combination of the clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 technique with the piggybac transposon system for mouse in utero electroporation to study cortical development. Journal of Neuroscience Research, 94(9): 814-824.

5. Chen H., Guo S., Li Z., Lu Y., Jiang D., Zhang R., Lei H., Gao L., Zhang X., Zhang Y., Wang L., Zhu L., Xiang M., Zhou Y., Wan Q., Dong H., Liu D., Li H.* (2014) A Critical Role for Interferon Regulatory Factor 9 in Cerebral Ischemic Stroke. Journal of Neuroscience, 34(36): 11897-912.

6. Lu, Y., Li, Z., Jiang, D., Wang, L., Zhang, Y., Chen, K., Zhang, X., Liu, Y., Fan, G., Chen, Y., Yang, Q., Zhou, Y., Zhang, X., Liu, D., Li, H.* (2013) TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death. Nature Communications, 4: 2852.

7. Zhou, Y.* (2012) Cortical development and asymmetric cell division. Frontiers in Biology, 7(4): 297-306.

8. Zhou, Y., Atkins, J., Rompani, S., Bancescu, D., Tang, H., Petersen, P., Zou, K., Stewart, S., Zhong, W.* (2007) The mammalian Golgi regulates Numb signaling in asymmetric cell division by releasing ACBD3 during mitosis. Cell, 129 (1): 163-78 (highlighted in F1000)

9. Zhou, Y., Du, G., Hu, X., Yu, S., Liu, Y., Xu, Y., Huang, X., Liu, J., Yin, B., Fan, M., Peng, X., Qiang, B., Yuan, J.* (2005) Nectin-like molecule 1 is a protein 4.1 N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. Biochimica et Biophysica Acta-Biomembranes, 1669(2): 142-54

10. Tang, H., Rompani, S. B., Atkins, J. B., Zhou, Y., Osterwalder, T., and Zhong, W.* (2005). Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway. Molecular and Cellular Biology, 25: 2899-2909.

11. Zhou, Y., Hu, S., Huang, X., Zhou, H., Tan, X., Peng, X., Qiang, B., Yuan, J.* (2002) Construction of human and mouse brain cDNA libraries and isolation of full-length cDNAs. Progress in Natural Science, 12(6): 477-480

12. Wang, J., Zhou, Y., Yin, B., Du, G., Huang, X., Li, G., Shen, Y., Yuan, J., and Qiang, B.* (2001) ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines. Journal of Molecular Medicine, 79, 399-405.

13. Zhou, Y., Du, G., Wang, J., Chen, J., Yuan, J., Qiang, B.* (1999) Isolation and cloning of a novel cDNA LDB1 encoding human LIM domain binding protein. Chinese Science Bulletin, 44(12): 1114-1119.

Tel: 0086-27-68750205 Fax: 0086-27-68759675  Email: mri@whu.edu.cn

Contact address: Donghu Road, No. 115, Wuchang District, Wuhan, Hubei Province, P.R. China. 430071

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