Rui Xiao
Author:  Date:2018-05-21  Clicks:



Rui Xiao, PhD

Professor, Principle Investigator

Medical Research Institute, Wuhan University

Email: xiaorui9@whu.edu.cn

 


Education:

1999-2003 B.A. in Biotechnology,

College of Life Sciences, Wuhan University, China  

2004-2010 PhD in Biochemistry and Molecular Biology,

College of Life Sciences, Wuhan University, China  


Professional Experience:

2011-2017    Postdoctoral Researcher

   Department of Cellular and Molecular Medicine, UC San Diego, USA

2017- Now   Professor, Medical Research Institute, Wuhan University, China


Research Interests:

RNA biology and transcription regulation

The RNA world is expanding and the functional significance of regulatory RNAs is gradually uncovered in diverse biological pathways. In RNA metabolism, RNA-binding proteins (RBPs), participating RNA splicing, packaging, transport, cellular localization, stability, translation and degradation, are crucial for the functions of RNAs. Currently, we broke into a new territory that RNA-binding proteins are prevalently involved in direct transcription regulation. Additionally, extensive genetic studies and Genome Wide Association Studies (GWASs) revealed that numerous human diseases are highly associated with RBP mutations. Our lab employs the latest high-throughput sequencing techniques, such as CLIP-seq, RNA-seq, ChIP-seq, GRO-seq, Hi-C and GRID-seq to systematically investigate the biological functions and molecular mechanism of RBPs in human disease.


Publications:

1. Xiao, R.*, Tang, P.*, Yang, B., Huang, J., Zhou, Y., Shao, C., Li, H., Sun, H., Zhang, Y. and Fu, XD (2012) Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. Molecular Cell. 45(5):656-668.

2. Wang, L.*, Zhou, Y.*, Xu, L.*, Xiao, R.*, Lu, X., Chen, L., Chong, J., He, C., Fu, XD and Wang, D. (2015) Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature. 523(7562):621-625. (Co-first author)

3. Wei, C.*, Xiao, R.*, Chen, L.*, Cui, H.*, Zhou, Y.*, Xue, Y., Hu, J., Zhou, B., Tsutsui, T., Qiu, J., Li, H., Tang, L. and Fu, XD (2016) RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. Molecular Cell. 62(6):875-889. (Co-first author)

4. Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C., Xiao, R., Burge, C.B. and Fu, XD (2013) SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell. 153(4):855-68.

5. Chen, L., Chen, JY., Zhang, X., Gu, Y., Xiao, R., Shao, C., Tang, P., Qian, H., Luo, D., Li, H., Zhou, Y., Zhang, D., and Fu, XD (2017) R-ChIP using inactive RNase H reveals dynamic Coupling of R-loops with transcriptional pausing at gene promoters. Molecular Cell. 68(4): 745-57.



Tel: 0086-27-68750205 Fax: 0086-27-68759675  Email: mri@whu.edu.cn

Contact address: Donghu Road, No. 115, Wuchang District, Wuhan, Hubei Province, P.R. China. 430071

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